Area Editoriale

M.KOCH Scrive"Quality-related variables at hepatological websites.M. Fraquelli, D. Contea, C. Cammà, G. Casazza, D. Di Bonab, P. Rebullad and D. Pratia. Dig Liver Dis 2004; 36:533-538CHAR(13) + CHAR(10)

M.KOCH Scrive"An Evidence-Based medicine approach to Beta-blocker therapy in patients with cirrhosisJayant A. Talwalkar and Patrick S. Kamath.CHAR(13) + CHAR(10)Am J Med 2004; 116:759-766

M.KOCH Scrive"Role of Vitamin K2 in the Development of Hepatocellular Carcinoma in Women With Viral Cirrhosis of the Liver .CHAR(13) + CHAR(10)Daiki Habu, Susumu Shiomi, Akihiro Tamori, Tadashi Takeda,Takashi Tanaka, Shoji Kubo, Shuhei Nishiguchi. JAMA. 2004;292:358-361.CHAR(13) + CHAR(10)CHAR(13) + CHAR(10)

vito Scrive"Hereditary Hemochromatosis — A New Look at an Old DiseaseCHAR(13) + CHAR(10)Antonello PietrangeloCHAR(13) + CHAR(10)New Engl J Med, 2004;350:2383-2397CHAR(13) + CHAR(10)

”Sclerosing Cholangitis.” Mac Faul George R, Chapman Roger W . Current Opinion in Gastroenterology 2004 ; 20(3): 275-280

Asymptomatic primary biliary cirrhosis: clinical features, prognosis, and symptom progression in a large population based cohort .M I Prince, A Chetwynd, W L Craig, J V Metcalf and O F W James .Gut. 2004 Jun;53(6):865-70.

V.Annese Scrive"Management of Cirrhosis and AscitesCHAR(13) + CHAR(10)Pere Ginès, Andrés Cárdenas, Vicente Arroyo, Juan Rodés. New Engl J Med 2004;350:1646-1654.CHAR(13) + CHAR(10)

Modest weight loss and physical activity in overweight patients with chronic liver disease results in sustained improvements in alanine aminotransferase, fasting insulin, and quality of life”. J Hickman, J.R Johnsson, A D Clouston, J B Prins, S Ash, D M Purdie, E E Powell. Gut 2004;53:413-419.

M.Koch Scrive"A treatment algorithm for the management of chronic hepatitis B virus infection in the United States. Emmet B. Keeffe, Douglas T. Dieterich, Steve-huy B. Han, Ira M. Jacobson, Paul Martin, Eugene R. Schiff, Hillel Tobias, Teresa L. Wright. Clin Gast Hep 2004;2: 87-106CHAR(13) + CHAR(10)CHAR(13) + CHAR(10)CHAR(13) + CHAR(10)

V.Annese Scrive"Genetics of liver disease: immunogenetics and disease pathogenesis. PT Donaldson. Gut 2004;53:599-608CHAR(13) + CHAR(10)

V.Annese Scrive"Hepatitis B Virus Infection — Natural History and Clinical Consequences. Don Ganem, and Alfred M. Prince. New Engl J Med 2004;350:1118-1129.CHAR(13) + CHAR(10)

M.Koch Scrive"Ribavirin-Induced Pure Red-Cell Aplasia during Treatment of Chronic HepatitisCHAR(13) + CHAR(10)Tanaka N et al LETTERA ALL'EDITORECHAR(13) + CHAR(10) N Engl J Med 2004;350:1264-1265 CHAR(13) + CHAR(10)

V.Annese Scrive"Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance. Angelo Sangiovanni, Ersilio Del Ninno, Pierangelo Fasani, Cristina De Fazio, Guido Ronchi, Raffaella Romeo, Alberto Morabito, Roberto de Franchis, Massimo Colombo. Gastroenterology 2004;126:(4):1005-14.

Effect of antiviral treatment on evolution of liver steatosis in patients with chronic hepatitis C: indirect evidence of a role of hepatitis C virus genotype 3 in steatosis. Castera L, Hezode C, Roudot-Thoraval F, Lonjon I, Zafrani ES, Pawlotsky JM, Dhumeaux D. Gut 2004;53:420-424

Steatosis affects chronic hepatitis C progression in a genotype specific way.Rubbia-Brandt L, Fabris P, Paganin S, Leandro G, Male PJ, Giostra E, Carlotto A, Bozzola L, Smedile A, Negro F. Gut. 2004 Mar;53(3):406-412.

Serum markers detect the presence of liver fibrosis: A cohort study. William M.C. Rosenberg, Michael Voelker, Robert Thiel, Michael Becka, Alastair Burt, Detlef Schuppan, Stefan Hubscher, Tania Roskams, Massimo Pinzani, Michael J.P. Arthur. Gastroenterology. 2004 Dec;127(6):1704-13. Background & Aims: Histologic examination of a liver biopsy specimen is regarded as the reference standard for detecting liver fibrosis. Biopsy can be painful and hazardous, and assessment is subjective and prone to sampling error. We developed a panel of sensitive automated immunoassays to detect matrix constituents and mediators of matrix remodeling in serum to evaluate their performance in the detection of liver fibrosis. Methods: In an international multicenter cohort study, serum levels of 9 surrogate markers of liver fibrosis were compared with fibrosis stage in liver biopsy specimens obtained from 1021 subjects with chronic liver disease. Discriminant analysis of a test set of samples was used to identify an algorithm combining age, hyaluronic acid, amino-terminal propeptide of type III collagen, and tissue inhibitor of matrix metalloproteinase 1 that was subsequently evaluated using a validation set of biopsy specimens and serum samples. Results: The algorithm detected fibrosis (sensitivity, 90%) and accurately detected the absence of fibrosis (negative predictive value for significant fibrosis, 92%; area under the curve of a receiver operating characteristic plot, .804; standard error, .02; P

Short-term antiviral efficacy of BILN 2061, a hepatitis C virus serine protease inhibitor, in hepatitis C genotype 1 patients. Holger Hinrichsen, Yves Benhamou, Heiner Wedemeyer, Markus Reiser, Roel E. Sentjens, José L. Calleja, Xavier Forns, Andreas Erhardt, Jens Crönlein, Ricardo L. Chaves, Chan-Loi Yong, Gerhard Nehmiz, Gerhard G. Steinmann. Gastroenterology 2004;127:1347-1355