05/12/2007
Statine e rischio CCR: una meta-analisi…
Statins and the risk of colorectal cancer: a meta-analysis of 18 studies involving more than 1.5 million patients. Bonovas S, Filioussi K, Flordellis CS, Sitaras NM.J Clin Oncol. 2007 Aug 10;25(23):3462-8.
04/12/2007
Farmaci e rischio CCR
Risk of colorectal cancer in patients prescribed statins, nonsteroidal anti-inflammatory drugs, and cyclooxygenase-2 inhibitors: nested case-control study. Vinogradova Y, Hippisley-Cox J, Coupland C, Logan RF. Gastroenterology. 2007 Aug;133(2):393-402.
04/12/2007
Farmaci e rischio CCR
Risk of colorectal cancer in patients prescribed statins, nonsteroidal anti-inflammatory drugs, and cyclooxygenase-2 inhibitors: nested case-control study. Vinogradova Y, Hippisley-Cox J, Coupland C, Logan RF. Gastroenterology. 2007 Aug;133(2):393-402.
28/09/2007
PPI e rischio di K colon
Chronic Proton Pump Inhibitor Therapy and the Risk of Colorectal Cancer.Yang YX, Hennessy S, Propert K, Hwang WT, Sedarat A, Lewis JD. Gastroenterology. 2007 Jun 20;
28/09/2007
PPI e rischio di K colon
Chronic Proton Pump Inhibitor Therapy and the Risk of Colorectal Cancer.Yang YX, Hennessy S, Propert K, Hwang WT, Sedarat A, Lewis JD. Gastroenterology. 2007 Jun 20;
27/09/2007
L'alcol favorisce il cancro al colon
Lifetime and baseline alcohol intake and risk of colon and rectal cancers in the European prospective investigation into cancer and nutrition (EPIC). Ferrari P, Jenab M, Norat T, Moskal A, Slimani N, Olsen A, Tjonneland A, Overvad K, Jensen MK, Boutron-Ruault MC, Rohrmann S, Linseisen J, Boeing H, Bergmann M, Kontopoulou D, Trichopoulou A, Kassapa C, Masala G, Krogh V, Vineis P, Panico S, Tumino R, Gils CH, Peeters P, Bueno-de-Mesquita HB, Ocke MC, Skeie G, Lund E, Agudo A, Ardanaz E, Lopez DC, Sanchez MJ, Quiros JR, Amiano P, Berglund G, Manjer J, Palmqvist R, Guelpen BV, Allen N, Key T, Bingham S, Mazuir M, Boffetta P, Kaaks R, Riboli E, Clavel-Chapelon F, Morois S.Int J Cancer. 2007 Jul 19; [Epub ahead of print]
27/09/2007
L'alcol favorisce il cancro al colon
Lifetime and baseline alcohol intake and risk of colon and rectal cancers in the European prospective investigation into cancer and nutrition (EPIC). Ferrari P, Jenab M, Norat T, Moskal A, Slimani N, Olsen A, Tjonneland A, Overvad K, Jensen MK, Boutron-Ruault MC, Rohrmann S, Linseisen J, Boeing H, Bergmann M, Kontopoulou D, Trichopoulou A, Kassapa C, Masala G, Krogh V, Vineis P, Panico S, Tumino R, Gils CH, Peeters P, Bueno-de-Mesquita HB, Ocke MC, Skeie G, Lund E, Agudo A, Ardanaz E, Lopez DC, Sanchez MJ, Quiros JR, Amiano P, Berglund G, Manjer J, Palmqvist R, Guelpen BV, Allen N, Key T, Bingham S, Mazuir M, Boffetta P, Kaaks R, Riboli E, Clavel-Chapelon F, Morois S.Int J Cancer. 2007 Jul 19; [Epub ahead of print]
25/09/2007
CON BASSI LIVELLI DI COLESTEROLO SI RISCHIA IL CANCRO
Effect of the magnitude of lipid lowering on risk of elevated liver enzymes, rhabdomyolysis, and cancer: insights from large randomized statin trials. Alsheikh-Ali AA, Maddukuri PV, Han H, Karas RH.J Am Coll Cardiol. 2007 Jul 31;50(5):409-18.
25/09/2007
CON BASSI LIVELLI DI COLESTEROLO SI RISCHIA IL CANCRO
Effect of the magnitude of lipid lowering on risk of elevated liver enzymes, rhabdomyolysis, and cancer: insights from large randomized statin trials. Alsheikh-Ali AA, Maddukuri PV, Han H, Karas RH.J Am Coll Cardiol. 2007 Jul 31;50(5):409-18.
05/09/2007
Compliance a tre diverse strategie di screening del CCR
Comparing attendance and detection rate of colonoscopy with sigmoidoscopy and FIT for colorectal cancer screening. Segnan N, Senore C, Andreoni B, Azzoni A, Bisanti L, Cardelli A, Castiglione G, Crosta C, Ederle A, Fantin A, Ferrari A, Fracchia M, Ferrero F, Gasperoni S, Recchia S, Risio M, Rubeca T, Saracco G, Zappa M; SCORE3 Working Group-Italy.Gastroenterology. 2007 Jun;132(7):2304-12.
05/09/2007
Compliance a tre diverse strategie di screening del CCR
Comparing attendance and detection rate of colonoscopy with sigmoidoscopy and FIT for colorectal cancer screening. Segnan N, Senore C, Andreoni B, Azzoni A, Bisanti L, Cardelli A, Castiglione G, Crosta C, Ederle A, Fantin A, Ferrari A, Fracchia M, Ferrero F, Gasperoni S, Recchia S, Risio M, Rubeca T, Saracco G, Zappa M; SCORE3 Working Group-Italy.Gastroenterology. 2007 Jun;132(7):2304-12.
01/09/2007
Meta-analisi sulla chemio nel trattamento del K pancreas avanzato
Meta-analyses of chemotherapy for locally advanced and metastatic pancreatic cancer. Sultana A, Smith CT, Cunningham D, Starling N, Neoptolemos JP, Ghaneh P.J Clin Oncol. 2007 Jun 20;25(18):2607-15.
01/09/2007
Meta-analisi sulla chemio nel trattamento del K pancreas avanzato
Meta-analyses of chemotherapy for locally advanced and metastatic pancreatic cancer. Sultana A, Smith CT, Cunningham D, Starling N, Neoptolemos JP, Ghaneh P.J Clin Oncol. 2007 Jun 20;25(18):2607-15.
29/08/2007
Identificato gene legato al K colon
Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24. Zanke BW, Greenwood CM, Rangrej J, Kustra R, Tenesa A, Farrington SM, Prendergast J, Olschwang S, Chiang T, Crowdy E, Ferretti V, Laflamme P, Sundararajan S, Roumy S, Olivier JF, Robidoux F, Sladek R, Montpetit A, Campbell P, Bezieau S, O'shea AM, Zogopoulos G, Cotterchio M, Newcomb P, McLaughlin J, Younghusband B, Green R, Green J, Porteous ME, Campbell H, Blanche H, Sahbatou M, Tubacher E, Bonaiti-Pellie C, Buecher B, Riboli E, Kury S, Chanock SJ, Potter J, Thomas G, Gallinger S, Hudson TJ, Dunlop MG. Nat Genet. 2007 Jul 8; [Epub ahead of print]
29/08/2007
Identificato gene legato al K colon
Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24. Zanke BW, Greenwood CM, Rangrej J, Kustra R, Tenesa A, Farrington SM, Prendergast J, Olschwang S, Chiang T, Crowdy E, Ferretti V, Laflamme P, Sundararajan S, Roumy S, Olivier JF, Robidoux F, Sladek R, Montpetit A, Campbell P, Bezieau S, O'shea AM, Zogopoulos G, Cotterchio M, Newcomb P, McLaughlin J, Younghusband B, Green R, Green J, Porteous ME, Campbell H, Blanche H, Sahbatou M, Tubacher E, Bonaiti-Pellie C, Buecher B, Riboli E, Kury S, Chanock SJ, Potter J, Thomas G, Gallinger S, Hudson TJ, Dunlop MG. Nat Genet. 2007 Jul 8; [Epub ahead of print]
28/08/2007
Nuova terapia genica contro il cancro al pancreas
Targeted Expression of BikDD Eradicates Pancreatic Tumors in Noninvasive Imaging Models. Xie X, Xia W, Li Z, Kuo HP, Liu Y, Li Z, Ding Q, Zhang S, Spohn B, Yang Y, Wei Y, Lang JY, Evans DB, Chiao PJ, Abbruzzese JL, Hung MC. Cancer Cell. 2007 Jul;12(1):52-65.
28/08/2007
Nuova terapia genica contro il cancro al pancreas
Targeted Expression of BikDD Eradicates Pancreatic Tumors in Noninvasive Imaging Models. Xie X, Xia W, Li Z, Kuo HP, Liu Y, Li Z, Ding Q, Zhang S, Spohn B, Yang Y, Wei Y, Lang JY, Evans DB, Chiao PJ, Abbruzzese JL, Hung MC. Cancer Cell. 2007 Jul;12(1):52-65.
12/08/2007
Lo score RECIST è di utilità limitata anche nel GIST....
We should desist using RECIST, at least in GIST.Benjamin RS, Choi H, Macapinlac HA, Burgess MA, Patel SR, Chen LL, Podoloff DA, Charnsangavej C.J Clin Oncol. 2007 May 1;25(13):1760-4.
12/08/2007
Lo score RECIST è di utilità limitata anche nel GIST....
We should desist using RECIST, at least in GIST.Benjamin RS, Choi H, Macapinlac HA, Burgess MA, Patel SR, Chen LL, Podoloff DA, Charnsangavej C.J Clin Oncol. 2007 May 1;25(13):1760-4.
07/08/2007
L’acido folico non previene il K colon
Folic acid for the prevention of colorectal adenomas: a randomized clinical trial.Cole BF, Baron JA, Sandler RS, Haile RW, Ahnen DJ, Bresalier RS, McKeown-Eyssen G, Summers RW, Rothstein RI, Burke CA, Snover DC, Church TR, Allen JI, Robertson DJ, Beck GJ, Bond JH, Byers T, Mandel JS, Mott LA, Pearson LH, Barry EL, Rees JR, Marcon N, Saibil F, Ueland PM, Greenberg ER; Polyp Prevention Study Group. JAMA. 2007 Jun 6;297(21):2351-9.
07/08/2007
L’acido folico non previene il K colon
Folic acid for the prevention of colorectal adenomas: a randomized clinical trial.Cole BF, Baron JA, Sandler RS, Haile RW, Ahnen DJ, Bresalier RS, McKeown-Eyssen G, Summers RW, Rothstein RI, Burke CA, Snover DC, Church TR, Allen JI, Robertson DJ, Beck GJ, Bond JH, Byers T, Mandel JS, Mott LA, Pearson LH, Barry EL, Rees JR, Marcon N, Saibil F, Ueland PM, Greenberg ER; Polyp Prevention Study Group. JAMA. 2007 Jun 6;297(21):2351-9.
29/07/2007
Il test immunochimico è superiore al guaiaco nello screening CCR
Comparison of a guaiac based and an immunochemical faecal occult blood test in screening for colorectal cancer in a general average risk population.Guittet L, Bouvier V, Mariotte N, Vallee JP, Arsene D, Boutreux S, Tichet J, Launoy G. Gut. 2007 Feb;56(2):210-4.
15/07/2007
K colon: management dei pazienti anziani
Managing older patients with colorectal cancer. Sanoff HK, Bleiberg H, Goldberg RM. J Clin Oncol. 2007 May 10;25(14):1891-7.
08/07/2007
Alterazione genetica favorisce multifocalità del gastrinoma ...
Allelic deletion of the MEN1 gene in duodenal gastrin and somatostatin cell neoplasms and their precursor lesions. Anlauf M, Perren A, Henopp T, Rudolf T, Garbrecht N, Schmitt A, Raffel A, Gimm O, Weihe E, Knoefel WT, Dralle H, Heitz PU, Komminoth P, Kloppel G.Gut. 2007 May;56(5):637-44.
25/06/2007
Aspirina e prevenzione del cancro: uno studio di coorte....
A large cohort study of long-term daily use of adult-strength aspirin and cancer incidence. Jacobs EJ, Thun MJ, Bain EB, Rodriguez C, Henley SJ, Calle EE. J Natl Cancer Inst. 2007 Apr 18;99(8):608-15.
24/06/2007
EPO per il trattamento dell’anemia in pazienti neoplastici..
Randomized, double-blind, placebo-controlled trial of erythropoietin in non-small-cell lung cancer with disease-related anemia. Wright JR, Ung YC, Julian JA, Pritchard KI, Whelan TJ, Smith C, Szechtman B, Roa W, Mulroy L, Rudinskas L, Gagnon B, Okawara GS, Levine MN.J Clin Oncol. 2007 Mar 20;25(9):1027-32. Epub 2007 Feb 20.
06/06/2007
La sorveglianza endoscopica non migliora la mortalità del K colon operato
Surveillance endoscopy does not improve survival for patients with local and regional stage colorectal cancer.Ramsey SD, Howlader N, Etzioni R, Brown ML, Warren JL, Newcomb P. Cancer. 2007 Apr 4; [Epub ahead of print]
25/05/2007
Review sistematica sullo screening CCR mediante Hemoccult test
Screeningfor colorectal cancer using the faecal occult blood test, Hemoccult.Hewitson P,Glasziou P, Irwig L, Towler B, Watson E. Cochrane Database Syst Rev. 2007 Jan24;(1):CD001216.
24/05/2007
Adenomi del colon: una meta-analisi sulle metodiche diagnostiche
Meta-analysiscomparing CT colonography, air contrast barium enema, and colonoscopy. Rosman AS, Korsten MA. Am J Med.2007 Mar;120(3):203-210
20/05/2007
U.S. PSTF contraria all'uso dell’aspirina per prevenire il CCR
Theuse of aspirin for primary prevention of colorectal cancer: a systematic reviewprepared for the U.S. Preventive Services Task Force. Dube C, Rostom A, LewinG, Tsertsvadze A, Barrowman N, Code C, Sampson M, Moher D; U.S. PreventiveServices Task Force. AnnIntern Med. 2007 Mar 6;146(5):365-75.
14/05/2007
Instabilità microsatellitare nei K colon "dell’intervallo"
Microsatelliteinstability in interval colon cancers. Sawhney MS, Farrar WD, Gudiseva S,Nelson DB, Lederle FA, Rector TS, Bond JH. Gastroenterology. 2006Dec;131(6):1700-5.
13/05/2007
PET accurata ma non cambia management dei pazienti
04/05/2007
K esofago: meta-analisi su chemioterapia neodiuvante o convenzionale…
Survivalbenefits from neoadjuvant chemoradiotherapy or chemotherapy in oesophagealcarcinoma: a meta-analysis. Gebski V, Burmeister B, Smithers BM, Foo K, ZalcbergJ, Simes J; Australasian Gastro-Intestinal Trials Group. LancetOncol. 2007 Mar;8(3):226-34.
03/05/2007
EPO utile anche nei pazienti in trattamento chemioterapico
Erythropoietin:High Profile, High Scrutiny. Crawford J.J Clin Oncol. 2007 Feb 20; [Epub aheadof print]
11/04/2007
Celecoxib è utile anche nella profilassi del cancro gastrico
Chroniccelecoxib users more often show regression of gastric intestinal metaplasiaafter Helicobacter pylori eradication. Yang HB, Cheng HC, Sheu BS, Hung KH,Liou MF, Wu JJ.CHAR(13) + CHAR(10)Aliment Pharmacol Ther. 2007 Feb15;25(4):455-61.
03/04/2007
I medici di base USA chiedono troppe colonscopie …
Colorectalscreening after polypectomy: a national survey study of primary care physicians.Boolchand V, Olds G, Singh J, Singh P, Chak A, Cooper GS.Ann Intern Med. 2006Nov 7;145(9):654-9.
28/03/2007
Sopravvivenza dopo resezione di metastasi epatiche
Survival after hepatic resection in metastatic colorectal cancer: apopulation-based study.Cummings LC, Payes JD, Cooper GS.Cancer. 2007 Jan 19; [Epub ahead of print]
23/03/2007
Il medicare ci conferma che lo screening per il CCR è efficace
Relationbetween Medicare screening reimbursement and stage at diagnosis for olderpatients with colon cancer. Gross CP,Andersen MS, Krumholz HM, McAvay GJ, Proctor D, Tinetti ME.JAMA.2006 Dec 20;296(23):2815-22.
21/03/2007
ACE-inibitori utili nella terapia delle metastasi epatiche da CRC
CHAR(13) + CHAR(10)Effectof ACE inhibitors and angiotensin II receptor antagonists in a mouse model ofcolorectal cancer liver metastasesJaclynH Neo , Cathy Malcontenti-Wilson , Vijayaragavan Muralidharan , ChristopherChristoph Journal of Gastroenterology and Hepatology , Publishedarticle online: 15-Dec-2006
05/03/2007
XELOX + radioterapia efficaci nel cancro rettale….
Multicenterphase II trial of chemoradiation with oxaliplatin for rectal cancer.RodelC, Liersch T, Hermann RM, Arnold D, Reese T, Hipp M, Furst A, Schwella N,Bieker M, Hellmich G, Ewald H, Haier J, Lordick F, Flentje M, Sulberg H,Hohenberger W, Sauer R. JClin Oncol. 2007 Jan 1;25(1):110-7.
03/03/2007
CRC : RM e TC virtuali hanno simile accuratezza..
Magnetic resonance colonography vscomputed tomography colonography for the diagnosis of colorectal cancer: anindirect comparison.Purkayastha S, Athanasiou T, Tekkis PP, Constantinides V,Teare J, Darzi AW. Colorectal Dis. 2007Feb;9(2):100-11.
28/02/2007
Malattia coronarica associata a K colon….
Prevalence of colorectal neoplasm among patients with newly diagnosed coronary artery disease.Chan AO, Jim MH, Lam KF, Morris JS, Siu DC, Tong T, Ng FH, Wong SY, Hui WM, Chan CK, Lai KC, Cheung TK, Chan P, Wong G, Yuen MF, Lau YK, Lee S, Szeto ML, Wong BC, Lam SK. JAMA. 2007 Sep 26;298(12):1412-9.
21/02/2007
Nuovi modelli predittivi per la syndrome di Lynch
Prediction ofgermline mutations and cancer risk in the Lynch syndrome. Chen S, Wang W, LeeS, Nafa K, Lee J, Romans K, Watson P, Gruber SB, Euhus D, Kinzler KW, Jass J,Gallinger S, Lindor NM, Casey G, Ellis N, Giardiello FM, Offit K, Parmigiani G;Colon Cancer Family Registry.JAMA. 2006 Sep 27;296(12):1479-87.
17/02/2007
Le statine non prevengono il cancro del colon
Statinuse and risk of colorectal cancer. Coogan PF, Smith J, Rosenberg L. J NatlCancer Inst. 2007 Jan 3;99(1):32-40.
12/02/2007
ATTIVITà FISICA CONTRO IL RISCHIO CANCRO AL COLON
Physicalactivity and risk of colon and rectal cancers: the European prospectiveinvestigation into cancer and nutrition. FriedenreichC, Norat T, Steindorf K, Boutron-Ruault MC, Pischon T, Mazuir M,Clavel-Chapelon F, Linseisen J, Boeing H, Bergman M, Johnsen NF, Tjonneland A,Overvad K, Mendez M, Quiros JR, Martinez C, Dorronsoro M, Navarro C, Gurrea AB,Bingham S, Khaw KT, Allen N, Key T, Trichopoulou A, Trichopoulos D, Orfanou N,Krogh V, Palli D, Tumino R, Panico S, Vineis P, Bueno-de-Mesquita HB, PeetersPH, Monninkhof E, Berglund G, Manjer J, Ferrari P, Slimani N, Kaaks R, RiboliE. CancerEpidemiol Biomarkers Prev. 2006 Dec;15(12):2398-407.
16/01/2007
Meta-analisi sul follow-up dopo resezione del K colon
Follow-Up After Curative Resection of Colorectal Cancer: A Meta-Analysis.Tjandra JJ, Chan MK. Dis Colon Rectum. 2007 Sep 15;
14/01/2007
Indicatori di qualità della chirurgia colorettale
Development ofquality indicators for patients undergoing colorectal cancer surgery. McGoryML, Shekelle PG, Ko CY. J Natl Cancer Inst.2006 Nov 15;98(22):1623-33.
12/01/2007
Aspirina e K colon : uno studio di coorte....
Long-termaspirin use and colorectal cancer risk: a cohort study in Sweden. Larsson SC, Giovannucci E, Wolk A. BrJ Cancer. 2006 Nov 6;95(9):1277-9. Epub 2006 Oct 24.
06/01/2007
K retto: RMN predittiva del successo della chirurgia
Diagnostic accuracyof preoperative magnetic resonance imaging in predicting curative resection ofrectal cancer: prospective observational study. MERCURY Study Group. BMJ. 2006 Oct14;333(7572):779.
04/01/2007
Colina, betaina e rischio di K colon
Dietary choline and betaine and the risk of distal colorectal adenoma in women. Cho E, Willett WC, Colditz GA, Fuchs CS, Wu K, Chan AT, Zeisel SH, Giovannucci EL. J Natl Cancer Inst. 2007 Aug 15;99(16):1224-31.
03/01/2007
Elevato rischio di tromboembolismo arterioso in corso di terapia con bevacizumab
Arterial thromboembolic events in patients with metastatic carcinoma treated with chemotherapy and bevacizumab. Scappaticci FA, Skillings JR, Holden SN, Gerber HP, Miller K, Kabbinavar F, Bergsland E, Ngai J, Holmgren E, Wang J, Hurwitz H. J Natl Cancer Inst. 2007 Aug 15;99(16):1232-9.